Understanding neuromodulation biophysics

Qualitative and quantitative understanding of acoustic, thermal and optogenetic neuronal excitation are key for effective neuromodulation. The Neural Intramembrane Cavitation Excitation (NICE) and Mechano-Electrical Thermal Activation (META) models, based on novel concepts for bio-acoustic and neuro-thermal interactions at the membrane level, are currently the only predictive models explaining these phenomena. Their predictions have excellent agreement to essentially the entire current body of experimental results in these emerging fields.  We are also developing new analytical and numerical tools for modeling light transport and interaction in optogenetics and other complex neuro-physical interactions.

Selected Publications: