We develop and explore acoustic and optical methods aimed at advancing the performance of large-scale optical imaging and control of network activity patterns towards whole-brain interfacing.
Reviews:
- Deán-Ben X. L., Gottschalk S., Mc Larney B., Shoham S. & Razansky D., Advanced optoacoustic methods for multiscale imaging of in vivo dynamics, Chemical Society Review, 46(8), 2158-2198 (2017). doi: 10.1039/C6CS00765A.
- Naor O.*, Krupa S.* & Shoham S., Ultrasonic neuromodulation, Journal of Neural Engineering, 13(3), 031003 (2016). doi: 10.1088/1741-2560/13/3/031003.
Selected publications:
- Gottschalk S., Degtyaruk O., McLarney B., Rebling J., Hutter M. A., Deán-Ben X. L., Shoham S.† & Razansky D.†, Rapid volumetric optoacoustic imaging of neural dynamics across the mouse brain, Nature Biomedical Engineering, (2019). doi:10.1038/s41551-019-0372-9.
- Boutte R. W., Merlin S., Yona G., Griffiths B., Angelucci A., Kahn I., Shoham S. & Blair S., Utah optrode array customization using stereotactic brain atlases and 3-D CAD modeling for optogenetic neocortical interrogation in small rodents and nonhuman primates, Neurophotonics, 4(4), 041502 (2017). doi: 10.1117/1.NPh.4.4.041502.
- Deán-Ben X. L.*, Sela G.*, Lauri A.*, Kneipp M., Ntziachristos V., Westmeyer G.†, Shoham S.† & Razansky D.†, Functional optoacoustic neuro-tomography (FONT) for scalable whole-brain monitoring of calcium indicators, Light: Science & Applications, 5, e16201(2016). doi: 10.1038/lsa.2016.201.
- Farah N., Levinsky A., Brosh I., Kahn I. & Shoham S., Holographic fiber bundle system for patterned optogenetic activation of large-scale neuronal networks, Neurophotonics, 2(4), 045002 (2015). doi: 10.1117/1.NPh.2.4.045002.
- Naor O.*, Hertzberg Y.*, Zemel E., Kimmel E. & Shoham S.,Towards multifocal ultrasonic neural stimulation II: design considerations for an acoustic retinal prosthesis, Journal of Neural Engineering, 9(2), 026006 (2012). doi: 10.1088/1741-2560/9/2/026006.
Neural Interface Engineering Lab 